Cancer Cell Plasticity Laboratory

Shen lab aims to understand how tumor cells rapidly adopt diverse cell states to adapt to anticancer therapies. Using both in vitro and in vivo models, we focus on melanoma and small-cell lung carcinoma, working with clinicians to translate our bench discoveries to the bedside.

About Us

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Team news

New spotlight published!

Illuminating a Dark Kinase in the Mesenchymal Cancer Cell State
@Cancer Discovery ，2025-03

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New commentary published!

Reflections on Advances in Cancer Research in 2024
@Cancer Discovery ，2024-12

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New review published!

Metabolism and mRNA translation: a nexus of cancer plasticity
@Trends in Cell Biology，2024-11

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New roadmap published!

Cancer drug-tolerant persister cells: from biological questions to clinical opportunities
@Nature Reviews Cancer ，2024-9

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New article published!

Plasma proteometabolome in lung cancer: exploring
biomarkers through bidirectional Mendelian
randomization and colocalization analysis
@Human Molecular Genetics，2024-07

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New article published!

Multicellular ecotypes shape progression of lung adenocarcinoma from ground-glass opacity toward advanced stages
@Cell Reports Medicine ，2024-3

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New review published!

Drug-tolerant persister cells in cancer: the cutting edges and future directions
@Nature Reviews Clinical Oncology，2023-9

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New review published!

Immunotherapy for Recurrent Glioma-From Bench to Bedside
@Cancers ，2023-6

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New article published!

Spatial patterns of the cap-binding complex eIF4F in human melanoma cells
@Comput Struct Biotechnol Journal，2023-01

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New review published!

Editorial: Non-genetic adaptive drug resistance in cancer
@Frontiers in Cell and Developmental Biology，2022-11

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Research Themes

Cancer Persister Cell

Persister cells are a small sub-population of cancer cells that maintain viability under anti-cancer treatments. These cells harbor non-genetic, reversible drug-resistance phenotypes. We are interested in understanding the underlying biological mechanisms.

Adaptive metabolism

Aberrant metabolism of cancer cells presents potential therapeutic opportunities. A growing interest focuses on how to target cancer metabolism. We are interested in metabolic rewiring in melanoma and lung cancers, paving the way to find new metabolic targets

Single cell analysis

Translating findings from single cell studies to clinical implementations of personalized medicine, paving the way to understand the heterogeneity of tumor intrinsic features, its microenvironment and tumor cell “quorum sensing” in the niche.